Lifelong effects of neuropeptides in the brain

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– The idea is to test whether other neuropeptides can also affect the development of the nervous system and thereby create a broader understanding of how specific receptor systems make it possible to distinguish between positive and negative effects, adds Tomas Hökfelt, professor emeritus at the department of neuroscience, who co-led the study .

Since many peptide receptors have previously been identified as targets for drug development, such studies could provide a new direction for the treatment of developmental/congenital diseases, where galanin and other neuropeptides may be involved.

Publication

Transient expression of the neuropeptide galanin modulates peripheral-to-central connectivity in the somatosensory thalamus during whisker development in mice.
Hevesi Z, Bakker J, Tretiakov EO, Adori C, Raabgrund A, Barde SS, Caramia M, Krausgruber T, Ladstätter S, Bock C, Hökfelt T, Harkany T
Nat Commun 2024 Mar;15(1):2762